Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
نویسندگان
چکیده
منابع مشابه
Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
Senescent cells, formed in response to physiological and oncogenic stresses, facilitate protection from tumourigenesis and aid in tissue repair. However, accumulation of such cells in tissues contributes to age-related pathologies. Resistance of senescent cells to apoptotic stimuli may contribute to their accumulation, yet the molecular mechanisms allowing their prolonged viability are poorly c...
متن کاملInhibition of Antiapoptotic BCL-XL, BCL-2, and MCL-1 Proteins by Small Molecule Mimetics
Informatics and computational design methods were used to create new molecules that could potentially bind antiapoptotic proteins, thus promoting death of cancer cells. Apoptosis is a cellular process that leads to the death of damaged cells. Its malfunction can cause cancer and poor response to conventional chemotherapy. After being activated by cellular stress signals, proapoptotic proteins b...
متن کاملPI3K/mTOR and Bcl-2/Bcl-xL inhibition in leukemia 1 Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism
Correspondence: Dr. Steven Grant, Division of Hematology/Oncology, MCV Station Box 230, Virginia Commonwealth University, Richmond, VA 23298, Phone: 804-828-5211, Fax: 804828-8079, Email: [email protected], or Dr. Mohamed Rahmani, Virginia Commonwealth University, Massey Cancer Center, 401 college street, P.O. Box 980035, Richmond VA 23298. Phone: 804-628-1976, Fax: 804-225-3788, E-mail: mrah...
متن کاملCombined inhibition of Notch signaling and Bcl-2/Bcl-xL results in synergistic antimyeloma effect.
Signaling through the receptor/transcriptional regulator Notch plays an important role in tumor cell survival. Recent studies have demonstrated that pharmacological inhibition of the Notch pathway with γ-secretase inhibitor (GSI) induces apoptosis of multiple myeloma (MM) cells via upregulation of the proapoptotic protein Noxa. ABT-737, a novel BH3 mimetic, was shown to block Bcl-2 and Bcl-xL a...
متن کاملLYMPHOID NEOPLASIA Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells
1The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia; 2Department of Medical Biology, University of Melbourne, Melbourne, Australia; 3Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Australia; 4Children’s Cancer Centre, Monash Medical Centre, Clayton, Australia; 5Department of Research Oncology, Genentech, South San Francisco...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Communications
سال: 2016
ISSN: 2041-1723
DOI: 10.1038/ncomms11190